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UPSTATE MEDICAL UNIVERSITY
Syracuse, New York
Zucker School of Medicine at Hofstra/Northwell
New York, New York
Assistant Professor, Clinical Statistical Geneticist/Epidemiologist, Division of Genomic Diagnostics
Children's Hospital of Philadelphia | Perelman School of Medicine, University of Pennsylvania
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About Oliver Lab -- Emory University School of Medicine
Dr. Oliver has pursued studies of cystic fibrosis (CF) pathogenesis since 2009. She began her scientific career as a master’s student at Auburn University, where she characterized adaptive metabolic strategies by which Pseudomonas aeruginosa chronically establishes itself in the lungs of individuals with CF. After graduating with an M.S. in Microbiology, she worked one year as Lead Instructor for the “Genetics and Evolution” course at the University of Alabama in Huntsville. In 2012, Dr. Oliver enrolled in the Genetics graduate program at the University of Alabama at Birmingham to study CF disease mechanism. Her dissertation project utilized high-throughput yeast phenomics to identify novel genetic modifiers of the most common CF-causing variant (F508del-CFTR) and elucidated, for the first time, effects of ribosomal perturbation on CFTR synthesis, trafficking, and function. Dr. Oliver began postdoctoral training at Emory University in 2017 and continued to work towards a career in basic and translational science. Her studies concentrated on evaluating changes in translation kinetics – both in vitro and in vivo – following suppression of specific ribosomal proteins. In 2021, Dr. ...Oliver was promoted to Assistant Professor of Pediatrics at Emory. Her current research program employs interdisciplinary approaches in molecular genetics, RNA biology, biochemistry, cellular physiology, and functional genomics to investigate impact of translational speed, ribosome fidelity, and mRNA surveillance on protein synthesis in the context of CF. Particular emphasis is placed on premature termination codons (PTCs) and other rare defects that occur in the CFTR gene, specifically evaluating underlying mechanism(s) responsible for genotype-phenotype correlation, pharmacologic responsiveness, and heterogeneity of patient outcomes. Dr. Oliver’s scientific objectives also include better delineation of genetic factors that influence severity of refractory CFTR variants, including attention to mutations that occur in non-Caucasian people with the disease. Her overarching goals are to provide new insights relevant to CF clinical intervention and extend research findings to other pediatric conditions with similar etiology. Dr. Oliver presently serves on the national CF Foundation (CFF) Clinical Guidelines Steering Committee and CFF Guidelines Committee for CF Related Metabolic Disorder and CF Screen Positive Inconclusive Disorder, as well as the CF Newborn Screening Committee within the Georgia Department of Public Health.
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