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Postdoctoral position in yeast genetics and molecular biology; DNA repair
I am looking for a postdoc to work on double-strand break repair in yeast. More specifically, we are interested in the origin of mutations arising during gene editing and other types of DNA repair. We have previously found that the mutation rate accompanying double-strand break repair is 1000 times higher than seen for spontaneous mutations in the same sequences. Moreover, the spectrum of mutations is very different, with many mutations reflecting the instability of the DNA repair polymerase complex, leading to increases in structural variants: deletions, tandem duplications, quasipalindrome mutations and interchromosomal template switches, even when the second template, on a different chromosome, is only 72% identical to the initial donor template, first described in (
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