Career Center

An instructor position is available to employ C. elegans to identify and study the function of genes that cause rare diseases in humans, as a component of the NIH Undiagnosed Diseases Network (UDN). As part of a team effort with other researchers and clinicians, candidate disease gene-variants are identified, knocked into the worm ortholog by Cas9/CRISPR and phenotype assessed. The development of a follow-up independent research program from one or more of the cases is possible. The project is performed under the guidance of professors Tim Schedl & Stephen Pak, co-directors of the Washington University School of Medicine Undiagnosed Diseases Network C. elegans Model Organism Screening Center.  For examples of publications from this project see: - Huang et al. A dominant negative